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Growth hormone release is concentrated during slow-wave sleep, and stimulant-related insomnia can blunt this process [15]
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Transcriptomic profiling of GlpNP-treated lesions revealed upregulation of contractile smooth muscle markers (ACTA2, MYH11) and downregulation of inflammatory genes ( IL1B , MMP9 ), supporting a mechanism of dual-cell reprogramming [197]